Objective To explore the level of bone metabolism and its clinical significance in patients with dilated cardiomyopathy (DCM). Methods Forty-eight patients with DCM who were treated in our hospital from March 2018 to March 2020 were selected as study subjects and classified into the DCM group. Thirty healthy adults who received physical examination in our hospital during the same period were selected and classified into the healthy group. Serum levels of BGP, ICa, BALP, PTH, 25(OH)D3, and other bone metabolic indicators were measured and compared between the two groups. Bone mineral density (BMD) of the greater trochanter, femoral neck, and lumbar spine was determined. The correlation of BGP, ICa, BALP, PTH and 25 (OH) D3 of bone metabolism indexes with patient age, DCM disease course, BMI, creatine kinase isoenzyme, troponin I and cardiac function grading was analyzed, respectively. Results (1) BGP, ICa, 25(OH)D3 and other levels in the DCM group were all lower than those in the healthy group, and BALP and PTH levels were higher than those in the healthy group, with statistically significant differences (all P < 0.05). (2) There was no significant difference in BMD between DCM group and healthy group (P>0.05). The BMD of the femoral neck and lumbar spine in the DCM group was lower than that in the healthy group, and the difference was statistically significant (All P < 0.05). (3) BGP, ICa, and 25 (OH) D3 were negatively correlated with age, DCM course, and grade of cardiac function, respectively. BGP was negatively correlated with creatine kinase isoenzyme and troponin I. BALP was positively correlated with age, DCM course, creatine kinase isoenzyme, troponin I, and cardiac function grade. PTH was positively correlated with cardiac function grade (all P < 0.05). Conclusion There was significant fluctuation in serum BGP, ICa, BALP, PTH, 25 (OH) D3 and other bone metabolic indicators in patients with DCM. Bone metabolism related indexes were related to the age, course of disease, cardiac function grade, cardiac troponin I, and creatine kinase isoenzyme in DCM patients. DCM may be an important reason for the disorder of bone metabolic indicators. |