Objective To investigate the influencing factors of lumbar osteoporosis (OP) in postmenopausal women with type 2 diabetes mellitus (T2DM). Methods A total of 186 postmenopausal women with T2DM who were admitted to the Department of Endocrinology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology from March 2018 to October 2019 were selected as subjects. The patients were divided into osteoporosis group (OP group) and non-osteoporosis Group (NOP group) according to T value of lumbar BMD. The general data were collected (age, height, weight, pregnancy times, birth times, age of menopause, course of DM, and family history of DM, hypertension history, fatty liver). HbA1C, FPG, Fins, and biochemistry were examined. BMD T values of the lumbar vertebrae and bone marrow fat content of the lumbar vertebrae and femur (LFC, FFC) were measured with dual energy X-ray absorptiometry. The difference of indexes between OP group and NOP group and the influencing factors of lumbar OP was analyzed using a SPSS 26.0 software. T test, non-parameter test, Chi-square test, Pearson and Searman correlation analysis, and binary logistic regression analysis were applied. P<0.05 was considered significant difference. Results Age, femoral marrow fat content, ALP, HBDH, LDH, menopausal years, pregnancy times, and birth times were higher in OP group than in NOP group (P<0.05). BMI and GGT were lower in OP group than in NOP group (P<0.05). There were no significant differences in FPG, Fins, HbA1C, course of DM, family history of DM, hypertension history, fatty liver, LFC, UA, Ca2+, Mg2+, TC, TG, and CK between the two groups (P>0.05). Binary logistic regression analysis of lumbar BMD showed that age, FFC, ALP, menopausal year, and birth times were the risk factors of lumbar OP (OR value was 1.131, 1.072, 1.029, 1.127, and 1.857, respectively). BMI was a protective factor for lumbar OP (OR=0.913). Conclusion Age, FFC, ALP, menopause year, and birth times are the risk factors of lumbar OP. BMI is the protective factor of lumbar OP. |