| In recent years, the incidence of lipid metabolism diseases represented by hyperlipidemia and bone metabolism diseases are increasing. The disorders of lipid metabolism can cause abnormal bone metabolism. Hyperlipidemia is one of the risk factors for bone metabolism-related diseases such as osteoporosis, and it usually has a negative regulatory effect on bone metabolism, which usually plays a negative role in the regulation of bone metabolism. Cholesterol, as the main component of blood lipids, has an important influence on the regulation of bone metabolism. This effect involves the relationship between cholesterol and osteoblasts/osteoclasts and the regulation of cholesterol on the selective differentiation of bone marrow mesenchymal stem cells at the molecular level. However, the mutual regulation mechanisms among these molecules are complex and diverse, which have not been fully elucidated so far. Therefore, this article mainly reviews the effect of cholesterol on osteoblasts/osteoclasts and explores the pathway mechanism of cholesterol on bone metabolism, in order to identify the targets of the correlation between cholesterol and bone metabolism, and to provide a novel direction for the prevention and treatment of bone metabolism diseases. |