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| 淫羊藿苷介导MAPK信号通路防治骨质疏松的研究进展 |
| Research progress of icariin mediated MAPK signaling pathway in prevention and treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2021.11.018 |
| 中文关键词: 淫羊藿苷 骨质疏松症 MAPK信号通路 成骨细胞 破骨细胞 |
| 英文关键词:icariin osteoporosis MAPK signaling pathway osteoblast osteoclast |
| 基金项目:国家自然科学基金项目（81760796；81960803）；广西自然科学基金青年基金（2020GXNSFBA159053）；广西高校青年教师基础能力提升项目(2019KY0352)；广西中医药大学2019年校级科研课 题（2019QN027）；广西中医药大学一流学科课题（2019XK029） |
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| 中文摘要: |
| 骨质疏松症(osteoporosis，OP)是以骨含量降低、骨密度下降、骨微结构破损、易发骨折为特征的骨科疾病，目前OP治疗主要以西药治疗为主，但疗效并不理想，所以有待进一步寻找根治OP的药物治疗方案。随着传统医学对OP研究的不断深入，发现淫羊藿苷可通过MAPK信号通路促进骨形成、改善骨代谢平衡、增加骨密度等，进而发挥抗OP作用。因此，本文将淫羊藿苷与MAPK信号通路相结合，以促进成骨细胞增殖分化、抑制破骨细胞分化、促进骨髓间充质干细胞成骨分化为治疗靶点综述淫羊藿苷介导MAPK信号通路防治骨质疏松的研究进展，以期为今后临床治疗OP提供新思路。 |
| 英文摘要: |
| Osteoporosis (OP) is an orthopedic disease characterized by decreased bone mass, decreased bone mineral density, damaged bone microstructure, and multiple fractures. At present, western medicine is the main treatment for OP, but the curative effect is not ideal. Therefore, it is necessary to find a drug treatment scheme to cure OP. With the development of traditional medicine research on OP, we find that icariin can promote bone formation, improve bone metabolism balance, and increase bone mineral density through MAPK signaling pathway, thus playing an anti-OP role. Therefore, we combine icariin and MAPK signaling pathway to promote osteoblast proliferation and differentiation, to inhibit osteoclast differentiation, and to promote osteogenic differentiation of bone marrow mesenchymal stem cells. The research progress of icariin mediated MAPK signaling pathway in the prevention and treatment of osteoporosis is reviewed in order to provide new ideas for clinical treatment of OP in the future. |
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