| Tissue engineered bone (TEB), due to its wide range of materials, excellent osteoconductivity, and osteoinductive capacity, has shown broad prospects in the treatment of large-scale bone defects and bone regeneration. The angiogenesis process of TEB and bone defect are extremely complex, requiring the participation of seed cells and various growth factors produced by cells. Mesenchymal stem cells (MSCs) are readily available, have less ethical controversy and low immunogenicity, and have the ability of osteogenic and angiogenic differentiation. It has been used as a new method to repair bone defects, which can overcome the shortcomings of the existing treatment methods and improve the clinical treatment effect. AMP-activated protein kinase (AMPK) is an important molecule that regulates cell energy homeostasis and a variety of metabolism-related hormones in eukaryotes. It can be activated by many pathways to play a physiological regulatory role. In recent years, studies have found that it is related to physiological processes of bone regeneration and bone microenvironment formation. It exerts an osteogenic effect by acting on MSCs, osteoblasts, osteoclasts, and angiogenesis. Many researchers have used AMPK and MSCs in combination to treat regeneration and repair of bone injury, which has a positive effect on TEB in promoting bone regeneration. In addition, this article also concludes that AMPK is involved in bone regeneration, which may be related to signal pathways such as reactive oxygen species, autophagy, and silent information regulator 1. This paper reviews the research and mechanism of AMPK in TEB promoting bone regeneration, aiming to provide theoretical basis and new ideas for bone defect repair, targeted therapy of bone regeneration and related molecular mechanisms. |