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| 绝经后骨质疏松性椎体压缩性骨折患者血清雌激素、前脂肪因子-1水平与骨代谢和骨密度相关性研究 |
| Study on the relationship between serum estrogen, preadipose factor-1, bone metabolism and bone mineral density in patients with postmenopausal osteoporotic vertebral compression fracture |
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| DOI：10.3969/j.issn.1006-7108.2021.12.008 |
| 中文关键词: 骨质疏松性椎体压缩性骨折 雌激素 前脂肪因子-1 骨代谢 骨密度 |
| 英文关键词:osteoporotic vertebral compression fracture estrogen preadipose factor-1 bone metabolism bone mineral density |
| 基金项目:湛江市科技攻关计划项目(2018B01049) |
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| 中文摘要: |
| 目的 研究绝经后骨质疏松性椎体压缩性骨折（osteoporotic vertebral compression fracture，OVCF）患者血清雌激素、前脂肪因子-1（preadipose factor-1，Pref-1）水平与骨代谢和骨密度的相关性。方法 纳入湛江中心人民医院2019年1月至2020年11月期间确诊的64例绝经OVCF患者为OVCF组，同时纳入绝经后的健康女性45名为对照组，比较OVCF组和对照组血清中雌二醇、Pref-1水平，并根据OVCF患者血清中雌二醇、Pref-1的水平分为高低亚组，进行患者骨代谢、骨密度等一系列指标的比较，通过Preason相关性分析雌二醇、Pref-1的水平与骨代谢、骨密度指标的相关性。结果 OVCF患者血清中雌二醇水平较对照组显著降低（t=13.275,P<0.05），Pref-1水平显著上升（t=10.360,P<0.05）；雌二醇高表达组较低表达组患者血清中25-（OH）VitD、N-MID的水平以及腰椎骨密度、髋部骨密度均显著上升（t=7.378,5.472,10.290,9.774,P<0.05），PINP、β-CTX水平均显著降低（t=6.447,9.103,P<0.05）；Pref-1高表达组较低表达组患者血清中25-（OH）VitD、N-MID的水平以及腰椎骨密度、髋部骨密度均显著下降（t=8.350,7.426,12.376,10.450,P<0.05），PINP、β-CTX水平均显著升高（t=8.266,11.205,P<0.05）；OVCF患者血清雌二醇水平与25-（OH）VitD、N-MID以及腰椎骨密度、髋部骨密度均呈正相关（r>0,P<0.05），与PINP、β-CTX水平呈负相关（r<0,P<0.05）；Pref-1与25-（OH）VitD、N-MID的水平及腰椎骨密度、髋部骨密度均呈负相关（r<0,P<0.05），与PINP、β-CTX水平呈正相关（r>0,P<0.05）。结论 绝经后OVCF患者血清雌激素显著下调，Pref-1水平明显上调，且二者与骨代谢和骨密度指标之间存在密切相关性，对二者水平的医学干预或能为OVCF的临床治疗带来新的契机。 |
| 英文摘要: |
| Objective To study the serum levels of estrogen and preadipose factor-1 in postmenopausal osteoporotic vertebral compression fracture (OVCF) patients and correlation with bone and bone mineral density. Methods A total of 64 menopausal OVCF patients diagnosed in our hospital from January 2019 to November 2020 were divided into OVCF group and 45 healthy postmenopausal women as control group. The levels of estradiol and Pref-1 were compared. The patients with OVCF were divided into high and low groups, and a series of indexes such as bone metabolism and bone mineral density were compared. The correlations between the levels of estradiol, Pref-1, bone metabolism and mineral were analyzed by Preason. Results The level of estradiol in OVCF was significantly lower than control (t=13.275, P<0.05), while the level of Pref-1 was significantly higher (t=10.360, P<0.05). The levels of 25-(OH) VitD and N-MID in the serum of patients in the lower expression group of estradiol high expression group, as well as lumbar vertebrae density and hip bone density, all increased significantly (t=7.378, 5.472, 10.290, 9.774, P<0.05),The expression level of PINP and β-CTX decreases （t=6.447, 9.103, P<0.05）.The levels of 25- (OH) VitD and N-MID as well as lumbar bone density and hip bone density were significantly decreased in the lower expression group in the high Pref-1 expression group t=8.350, 7.426, 12.376, 10.450, P<0.05),The PINP, β-CTX levels were all significantly increased（t=8.266,11.205, P<0.05）.The serum estradiol in OVCF was positively correlated with 25-(OH) VitD, N-MID and hip bone mineral（r>0, P<0.05）, but negatively correlated with PINP and β-CTX（r＞0,P<0.05）. Pref-1 was inversely associated with 25- (OH) VitD, N-MID levels, and lumbar bone density, and hip bone density（r<0,P<0.05）, Positive correlation was observed with PINP, β-CTX levels（r>0, P<0.05）. Conclusion Serum estrogen level is significantly down-regulated and Pref-1 level is significantly up-regulated in postmenopausal OVCF patients, and they are closely related to bone metabolism and bone mineral density. Medical intervention on the two levels may bring new opportunities for clinical treatment of OVCF. |
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