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| VIBE-Dixon序列骨髓脂肪定量与骨密度在女性骨质疏松症评价的研究 |
| A comparative study of VIBE-Dixon sequence bone marrow fat quantification and bone mineral density in the evaluation of female osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2021.12.010 |
| 中文关键词: 骨密度 绝经后女性 腰椎 脂肪含量 VIBE-Dixon |
| 英文关键词:bone density postmenopausal women lumbar spine fat content VIBE-Dixon |
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| 中文摘要: |
| 目的 探讨扫描层厚、翻转角对VIBE-Dixon序列测量腰椎骨髓脂肪分数的影响，探讨脂肪分数与骨密度(bone mineral density, BMD)的相关性，确定其与年龄、体质量指数（body mass index, BMI)、绝经、运动的关系。方法 选取116名符合纳入标准的志愿者，行腰椎MRI VIBE-Dixon扫描和DXA扫描。测量L1~4椎体骨髓的脂肪分数和骨密度。用组内相关性评估测量可重复性。采用Pearson线性相关分析评价2 mm与4 mm层厚的测量结果。采用Pearson线性相关分析评价5°、10°、15°翻转角得到的腰椎脂肪分数与骨密度的相关性。对年龄分组、BMI分组、运动情况分组均采用单因素方差分析，对绝经组与非绝经组采用t检验。结果 经两名技术专家测量的组内相关系数ICC=0.983。不同层厚结果之间存在明显相关性[r=0.981 (5°)，0.969 (10°)，0.972 (15°)；P均﹤0.05]。不同翻转角、不同层厚结果与骨密度之间存在中度相关性[r=0.702 (2 mm-5°),0.732 (2 mm-10°),0.703(2 mm-15°),0.697(4 mm-5°),0.700(4 mm-10°), 0.714(4 mm-15°); P均﹤0.05]。腰椎椎体脂肪分数随年龄增加呈上升趋势，不同年龄组间差异有统计学差异[F=31.87(2 mm-5°), 28.41(2 mm-10°), 28.69 (2 mm-15°), 34.11(4 mm-5°), 34.05(4 mm-10°), 32.82(4 mm-15°); P﹤0.05]。腰椎椎体脂肪分数随BMI增加呈上升趋势；绝经女性FF值明显高于非绝经女性；运动强度对FF值没有影响。结论 VIBE-Dixon测量腰椎椎体脂肪分数具有可重复性；层厚和翻转角对评估影响较小；腰椎椎体脂肪分数能较好反映骨质量，并与腰椎骨密度呈负相关。 |
| 英文摘要: |
| Objective To investigate the effect of scanning slice thickness and flip angle on lumbar bone marrow fat fraction (FF) measured by VIBE-Dixon sequence, to explore the correlation between FF and bone mineral density (BMD), and to determine the relationship between FF and age, body mass index (BMI), menopausal status and exercise. Methods Magnetic resonance imaging (MRI) VIBE-Dixon and dual energy X-ray absorptiometry (DXA) scans of the lumbar spine were performed in 116 volunteers who met the inclusion criteria. BMD and bone marrow FF of L1–4 were measured. The repeatability of measurement was evaluated by intra-group correlation. Pearson linear correlation analysis was used to evaluate the measurement results of slice thickness obtained by 2 mm and 4 mm scanning, and to evaluate the correlation between lumbar FF, obtained from 5°, 10° and 15° flip angles, and BMD. One-way ANOVA was used for all age groups, BMI groups and exercise groups, and a t-test was used for postmenopausal and non-postmenopausal groups. Results The intra-class correlation coefficient (ICC) of the results measured by two technical experts was 0.983. There was a significant correlation among different scan thicknesses [r=0.981 (5°)，0.969 (10°)，0.972 (15°)；P﹤0.05]. There was a moderate correlation between vertebral FF and BMD [r=0.702 (2 mm-5°),0.732 (2 mm-10°),0.703(2 mm-15°),0.697(4 mm-5°),0.700(4 mm-10°), 0.714(4 mm-15°); P﹤0.05]. The FF of lumbar vertebrae increased with age, and there were significant differences among different age groups [F=31.87(2 mm-5°), 28.41(2 mm-10°), 28.69(2 mm-15°), 34.11(4 mm-5°), 34.05(4 mm-10°), 32.82(4 mm-15°); P﹤0.05]. The FF of lumbar vertebrae increased with the increase of BMI; the FF value of postmenopausal women was significantly higher than that of non-postmenopausal women; and exercise intensity had no effect on FF value. Conclusions The lumbar body FF obtained by VIBE-Dixon had good repeatability; the slice thickness and flip angle had little influence on the evaluation; and the FF of lumbar vertebrae can partly reflect the bone mass and had a negative correlation with lumbar BMD. |
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