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| 301例脆性髋部骨折回顾性研究及文献共现分析 |
| Retrospective study of 301 cases of brittle hip fracture and co-occurrence analysis of the literature |
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| DOI：10.3969/j.issn.1006-7108.2021.12.016 |
| 中文关键词: 骨质疏松症 髋部骨折 真实世界研究 共现分析 |
| 英文关键词:osteoporosis hip fracture real world study co-occurrence analysis |
| 基金项目:国家自然科学基金面上项目（8197150751）;广州市科技计划项目（20212010463）;广州中医药大学第一附属医院“创新强院”临床研究专项项目（219IIT11）； |
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| 中文摘要: |
| 目的 分析确诊骨质疏松症后髋部骨折患者的发病特点及双膦酸盐类药物治疗史对院内治疗结局的影响。方法 回顾广州中医药大学第一附属医院一骨科10年间收治的确诊骨质疏松症后髋部骨折患者301例, 分析其发病特点，再按照是否有双膦酸盐类药物治疗史分为治疗组和未治疗组，对比两组患者住院特征差异，并开展文献研究，建立共现网络分析研究热点。结果 确诊骨质疏松症后继发髋部骨折人数占总髋部骨折人数的18.33%，好发于冬、春季，创伤原因多为低能量伤，中位发病年龄78岁，男女比1:4.68，治疗组患者发病年龄、住院天数、住院费用、手术率、手术等待时间显著低于未治疗组（P＜0.001），两组患者的院内抢救率、院内死亡率及31天再住院率方面比较差异无统计学意义（P＞0.05）。结论 骨质疏松后脆性骨折的发生规律符合髋部骨折整体发病规律，但女性发病率明显增加。双膦酸盐类药物治疗史有利于缩短住院时间、降低住院费用、减少手术治疗率及手术等待时间，研究内容符合当前研究热点。 |
| 英文摘要: |
| Objective To analyze the characteristics of hip fracture after diagnosis of osteoporosis and the influence of bisphosphonates treatment history on the outcome of in-hospital treatment. Methods A review of 301 patients with hip fractures after the diagnosis of osteoporosis admitted to the Department of orthopedics, the First Affiliated Hospital of Guangzhou University of traditional Chinese medicine in the past 10 years was reviewed, and their characteristics were analyzed. Results After the diagnosis of osteoporosis, the number of secondary hip fractures accounted for 18.33% of the total number of hip fractures, prone to occur in winter and spring, the cause of trauma was low energy injury, the median age of onset was 78 years old, the male to female ratio was 1: 4.68 Hospitalization days, hospitalization expenses, operation rate and waiting time of operation were significantly lower than those of the untreated group (P<0.001). There was no significant difference in the in-hospital salvage rate, in-hospital mortality rate and rehospitalization rate of the 31 groups between the two groups (P>0.05). Conclusion The incidence of brittle fracture after osteoporosis is in line with the overall incidence of hip fracture, but the incidence rate of female is significantly increased. The treatment history of bisphosphonates can shorten the length of hospital stay, reduce the cost of hospitalization, reduce the rate of surgical treatment and the waiting time of surgery. |
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