529例成年女性维生素D水平及其影响因素研究
Research of vitamin D levels and its influencing factors in 529 adult females
  
DOI:10.3969/j.issn.1006-7108.2021.12.017
中文关键词:  成年女性  血清25-羟维生素D  骨质疏松症  肥胖  影响因素
英文关键词:adult female  serum 25 hydroxyvitamin D  osteoporosis  obesity  influencing factors
基金项目:黑龙江省中医药科研项目(ZHY2020-123);全国中医药创新骨干人才项目;2020黑龙江省自然科学基金联合引导项目(LH2020H085);黑龙江中医药大学“优秀创新人才支持项目”(2018RCD13)
作者单位
李佳睿 杜丽坤2* 1.黑龙江中医药大学黑龙江 哈尔滨 150040 2.黑龙江中医药大学附属第一医院黑龙江 哈尔滨 150040 
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中文摘要:
      目的 回顾性分析529例成年女性血清25-羟维生素D[25 hydroxy vitamin D,25 ( OH) D]的水平及其影响因素,为骨质疏松症(osteoporosis,OP)及肥胖等疾病的防治提供依据。方法 选取2019年1月-2020年12月在黑龙江中医药大学附属第一医院接受血清25 (OH) D水平检测的成年女性,共计529人,其中19~28岁135人,29~38岁277人,39~48岁54人,49~58岁42人,59~68岁21人。采集受试者清晨空腹静脉血,应用酶联免疫法测定血清25 (OH) D浓度。以血清 25( OH)D<30 nmol /L 为维生素 D缺乏;血清 25 (OH) D在30~49.9 nmol /L为维生素D不足;血清 25 (OH) D≥50 nmol /L为维生素D充足。统计数据并登记受试者性别、年龄以及采集时间等基本信息,分析血清25 (OH) D水平的影响因素。结果 529例成年女性25 (OH) D平均水平为(19.98±8.58)ng /mL,其中19~28岁组为(18.14±8.02)ng /mL,29~38岁组为(20.44±8.26)ng /mL,39~48岁组为(20.04±10.14)ng /mL,49~58岁组为(20.94±8.55)ng /mL,59-68岁组为(23.64±10.34)ng /mL。19~28岁人群维生素D水平充足的占比最低。不同年龄组相比较(完全随机方差分析one way ANOVA检验),差异有统计学意义(F=2.88,P<0.05)。经非参数检验,不同季节间差异有统计学意义(α=0.05),夏季>秋季>春季>冬季。结论 哈尔滨市成年女性普遍存在维生素D不足,且与年龄及季节具有相关性。
英文摘要:
      Objective To analyze the serum level of 25-hydroxyvitamind [25- hydroxyvitamind, 25 (OH) D] in 529 adult females and its influencing factors, so as to provide evidence for the prevention and treatment of osteoporosis, obesity and other diseases. Methods A total of 529 adult woman underwent serum 25 (OH) D level testing in the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from January 2019 to December 2020. 135 of them aged between 19-28 years, 277 between 29-38 years, 54 between 39-48 years, 42 between 49-58 years, and 21 between 59-68 years. Fasting venous blood in the morning was collected and serum 25 (OH) D concentration was determined by enzyme-linked immunoassay. 25 (OH) D<30 nmol/L was considered as vitamin D deficiency. Vitamin D deficiency occurs when serum 25 (OH) D is between 30 and 49.9 nmol/L . Serum 25 (OH) D≥50nmol/L is suitable for vitamin D. Statistical data were collected and basic information such as gender, age and collection time of patients were recorded to analyze the influencing factors of serum 25 (OH) D level. Results The average level of 25 (OH) D in 529 adult women was (19.98±8.58) ng /mL. 19-28 years group was (18.14±8.02) ng /mL, 29-38 years group was (20.44±8.26) ng /mL, 39-48 years group was (20.04±10.14) ng /mL, 49-58 years group was (20.94±8.55) ng /mL, and 59-68 years group was (23.64±10.34) ng /mL. Comparison different age groups (complete random variance analysis one way ANOVA, F=2.88, P<0.05), and the differences were showed statistically significant. The proportion of people aged 19-28 with adequate vitamin D levels is the lowest. By non-parametric test, there was statistical significance among different seasons (α=0.05), summer > autumn > spring > winter. Conclusion Vitamin D deficiency is common in adult females in Harbin, and it is correlated with age and season.
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