Objective To investigate the relationship between transcutaneous oxygen pressure and bone mineral density (BMD) in postmenopausal women with type 2 diabetes, and to further understand the influence of microcirculation in BMD. Methods A total of 162 postmenopausal patients with type 2 diabetes were included in this cross-sectional study. BMD of the lumbar spine, hip, right femoral neck, Ward’s triangle, femoral trochanter, and intertrochanter was evaluated with dual-energy X-ray absorptiometry. According to the T score values, the patients were divided into three groups: osteoporosis group (T≤-2.5), bone loss group (-2.5<T<-1.0), and normal bone mass group (T≥-1.0). Perimed PeriFlux System 5000 was used to detect the transcutaneous partial pressure of oxygen of the bilateral knee and the dorsum of the foot, respectively. Transcutaneous partial pressure of oxygen was the primary detection method for microvascular lesions. The general characteristics of the three groups were compared. The correlation between BMD and transcutaneous oxygen partial pressure was analyzed with Pearson correlation coefficient analysis. The influencing factors of BMD were analyzed with multiple stepwise regression. Results The levels of TcPO2 and ABI in postmenopausal women with osteoporosis were lower than those in the healthy BMD group (40.09 vs. 47.89, 1.06 vs. 1.17, P<0.05). TcPO2 was positively correlated with BMD at the lumbar spine, femoral neck, femoral trochanter, intertrochanter, total hip, and Ward's triangle (r=0.259, 0.215, 0.226, 0.217, 0.213, 0.226, respectively). After adjusting for age, course of the disease, BMI, and menopausal years, TcPO2 was still positively correlated with BMD of the lumbar spine. Multiple stepwise regression analysis showed that TcPO2, BMI, and age were independent influencing factors of lumbar BMD, while TcPO2, BMI, calcium, and menopausal years were independent influencing factors of the femoral neck BMD. Conclusion Levels of TcPO2 and ABI decrease in type 2 diabetic postmenopausal women with osteoporosis. The decline in TcPO2 may be an independent influencing factor affecting the reduction in BMD in these patients. |