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| 新型炎症因子与原发性骨质疏松症的研究进展 |
| Research progress of novel inflammatory factors in primary osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2022.01.031 |
| 中文关键词: 中性粒细胞/淋巴细胞比率 全身免疫炎症指数 原发性骨质疏松症 炎症因子 免疫细胞 |
| 英文关键词:neutrophil-to-lymphocyte ratio systemic immune-inflammation index primary osteoporosis inflammatory factors immune cell |
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| 中文摘要: |
| 原发性骨质疏松症的发病机制至今仍未完全明确。骨骼免疫学的提出进一步映证了慢性炎症在骨质疏松症（osteoporosis,OP）发生中的重要作用，多项炎症因子及免疫细胞参与其中。中性粒细胞/淋巴细胞比率（neutrophil-to-lymphocyte ratio，NLR）、全身免疫炎症指数（systemic immune-inflammation index，SII）作为反映系统性炎症的指标，成本低廉，监测较稳定，具有明显的优势。目前已有研究证实它们可与其他炎症指标、骨转化标志物等相结合，实现OP早期诊断，甚至预测骨质疏松性骨折。与目前临床常用的OP筛查方法相比，可避免费时、费力及结果滞后等问题，提高患者的依从性，便于早期发现OP并及时干预。 |
| 英文摘要: |
| The pathogenesis of primary osteoporosis is extremely complex and has not been fully elucidated up to now.The development of bone immunology further demonstrates the important role of chronic inflammation in the development of osteoporosis, in which multiple inflammatory factors and immune cells are involved.As indicators reflecting systemic inflammation,neutrophil-to-lymphocyte ratio(NLR) and Systemic Immune-Inflammation Index (SII) are of low cost and stable monitoring, with obvious advantages. At present, studies have confirmed that they can be combined with other inflammatory indicators and markers of bone transformation to early diagnose osteoporosis and even predict osteoporotic fractures.Compared with the current screening methods for osteoporosis commonly used clinically, it can avoid time-consuming, laborious and delayed results, improve patients' compliance, and facilitate early detection of osteoporosis and timely intervention. |
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