| Objective To investigate the correlation between blood routine index and bone marrow fat content and bone mineral density in postmenopausal women. Methods Height, weight, red blood cell count, white blood cell count, and platelet count were measured in 72 postmenopausal women (aged 55-79 years). Bodymassindex (BMI) was calculated, and L3 bone marrow fat fraction (FF) was measured by magnetic resonance spectroscopy (MRS) scanning. Dual-energy X-ray absorptiometry（DXA) was determined. the lumbar spine (L1-4), left femoral neck and bone mineral density (BMD) were obtained by scanning. Repeatability of MRS scan was evaluated, red blood cell count, white blood cell count and platelet count were analyzed for their correlation with FF value and BMD value, and independent correlation factors of FF value were analyzed by multiple stepwise regression.Results The repeatability coefficient of variation (CV) was 2.86%.Red blood cell count, white blood cell count and platelet count were negatively correlated with FF (P<0.01). Red blood cell count, white blood cell count and platelet count had no correlation with bone mineral density of lumbar spine (L1-4) and bone mineral density of left femoral neck, but had negative correlation with bone mineral density of whole body (P<0.05). Further multiple stepwise regression analysis showed that after adjusting for age, height, weight, and BMI, red blood cell count, white blood cell count, and platelet count were independent negatively correlated factors affecting FF (P<0.05, R2=0.518). Conclusion Routine blood indicators (red blood cell count, white blood cell count, platelet count) and FF have a certain correlation with bone mineral density in postmenopausal women, and have a certain guiding role in the early diagnosis and prevention of osteoporosis in postmenopausal women. |