| Objective To investigate the correlation between serum osteocalcin (OC) level and skeletal muscle index (SMI) in patients with type 2 diabetes mellitus (T2DM). Methods The general data and experimental indexes of 550 T2DM patients were collected. The body composition, including limb skeletal muscle mass, bone mineral density (BMD), and whole body fat percentage were measured using dual energy X-ray absorptiometry (DEXA). According to SMI, the patients were divided into SMI normal group and SMI reduction group. The influencing factors of SMI were analyzed. Results The proportion of male patients, smoking history, drinking history, and patients with osteoporosis in SMI reduction group were higher than those in the SMI normal group. The levels of BMI, albumin, TG, PTH, lumbar BMD, femoral neck BMD, hip BMD, SMI, and whole body fat percentage in the SMI reduction group were lower than those in the SMI normal group (P < 0 05). SMI, lumbar BMD, femoral neck BMD, and hip BMD in males were higher than those in females, while OC and whole body fat percentage in males were lower than those in females. Age, BMI, percentage of body fat, HbAlc, albumin, UA, 25 (OH) D, and other confounding factors were included. There was a positive correlation between OC and SMI. Conclusion There is a positive correlation between serum OC and SMI in T2DM patients. Serum OC level may affect skeletal muscle mass and is one of the influencing factors of SMI. |