| Objective To explore the relationship between gene polymorphism in patients with osteoporosis (OP) and with intervertebral disc degeneration (IDD). Methods The gene expression profile of OP and IDD was obtained from GEO database. The difference genes were analyzed and the intersection was collected. PPI network was then constructed by using Cytoscape software. The key genes were screened out according to the degree value, and the relationship between OP and IDD was analyzed. Finally, the main biological function and signal pathway of the key genes in the process of OP and IDD development were analyzed by using David database. Results The results showed that there were 205 cross genes in the occurrence and development of OP and IDD. UBC, YWHAZ, TP53, CUL3, NTRK1, BRCA1, MCM2, and ESR1 were the key genes. The results of GO function analysis and KEGG enrichment analysis showed that the biological process closely related to the occurrence and development of OP and IDD mainly involved protein-DNA complex assembly, protein-DNA complex subunit organization, protein deubiquitination, protein modification by small protein removal, and regulation of chromosome organization. It also involved PI3K/Akt signaling pathway, ubiquitin mediated protein hydrolysis, mitochondrial autophagy, apoptosis pathways, neurotrophin signaling pathway, and thyroid hormone signaling pathway. Conclusion There is highly coincident gene expression between OP and IDD. The involved gene function and signal pathway are helpful to understand the common pathogenesis of the two diseases, and to provide certain reference for the common drug research and treatment of the two diseases. |