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| 相位角与住院老年慢病患者肌少症的相关性分析 |
| Correlation analysis between phase angle and sarcopenia in elderly hospitalized patients with chronic diseases |
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| DOI：10.3969/j.issn.1006.7108.2022.04.006 |
| 中文关键词: 生物电阻抗 相位角 肌少症 老年人 |
| 英文关键词:bioelectrical impedance analysis phase angle sarcopenia aged |
| 基金项目:国家临床重点专科能力建设项目；北京大学人民医院研究与发展基金（RDY2019-16） |
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| 中文摘要: |
| 目的 探索生物电阻抗分析（BIA）来源的测量值相位角（PhA）对肌少症的诊断和预测价值。方法 收集2018年8月至2019年12月于北京大学人民医院老年科住院且年龄≥60岁的患者235例。将患者分肌少症组 53 例和非肌少症组182例，通过Logistic回归分析明确PhA与肌少症及其各组成部分的相关性。通过受试者工作特征（ROC）曲线分析PhA对肌少症的预测价值，通过Jonckheere-Terpstra方法检验PhA随肌少症严重程度的趋势性变化。结果 多因素Logistic回归分析显示，PhA与肌少症、低四肢骨骼肌质量指数（ASMI）、低握力、低步速、低五次坐站测试表现、低简易躯体能力测试试验（SPPB）均独立相关，且随PhA值降低，肌少症（OR=4.21, 95 %CI=1.60~11.05, P=0.004）、低ASMI（OR=5.40, 95 %CI=2.10~13.91, P＜0.001）、低握力（OR=3.59, 95 %CI=1.83~7.03, P＜0.001）、低步速（OR=2.62, 95 %CI=1.38~5.00, P=0.003）、低五次坐站测试表现（OR=3.33, 95 %CI=1.70~6.54, P＜0.001）、低SPPB（OR=4.11, 95 %CI=2.00~8.46, P＜0.001）风险均升高。PhA诊断肌少症的最佳截断值：男性为4.35 °，女性为3.85 °。并且严重肌少症患者的PhA值更低。结论 PhA值与肌少症及其各组成部分相关，可以用于早期识别、诊断肌少症。 |
| 英文摘要: |
| Objective To explore the diagnostic and predictive value of phase angle (PhA) derived from bioelectrical impedance analysis (BIA) for sarcopenia. Methods 235 hospitalized patients aged≥60 years in the Department of Geriatrics, Peking University People's Hospital were collected from August 2018 to December 2019. The patients were divided into sarcopenia group (n=53) and non-sarcopenia group (n=182). The correlation between PhA and sarcopenia and its components were analyzed by logistic regression. The predictive value of PhA for sarcopenia was analyzed by receiver operating characteristic (ROC) curve, and the trend change of PhA with the severity of sarcopenia was tested by jonckheere-Terpstra method. Results Multivariate logistic regression analysis showed that low PhA was independently associated with sarcopenia, low appendicular skeletal mass index (ASMI), low handgrip strength, low gait speed, low 5-time chair stand test, low short physical performance battery, respectively. With the decrease of PhA, the risk of sarcopenia (OR=4.21, 95%CI=1.60-11.05, P=0.004), low ASMI (OR=5.40, 95%CI=2.10-13.91, P＜0.001), low handgrip strength (OR=3.59, 95%CI=1.83-7.03, P＜0.001), low gait speed (OR=2.62, 95%CI=1.38-5.00, P=0.003), low 5-time chair stand test (OR=3.33, 95%CI=1.70-6.54, P＜0.001), low SPPB (OR=4.11, 95%CI=2.00-8.46, P＜0.001) were increased. The best cut-off value of PhA in the diagnosis of sarcopenia was 4.35° for men and 3.85° for women. PhA value of patients with severe sarcopenia was lower. Conclusion PhA value is correlated with sarcopenia and its components, which can be used for early identification and diagnosis of sarcopenia. |
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