| Objective To explore the interaction mechanism between non-alcoholic fatty liver and osteoporosis through bioinformatics-related technologies and methods based on related databases. Methods Used osteoporosis and non-alcoholic fatty liver as keywords, the relevant genes were screened in related disease databases (Disgenet, TTD, OMIM, Drugbank, Genecards), and the two groups of predicted target genes were mapped after de-reintegration to obtain key targets Point, obtained the target PPI interaction network through the STRING website, screened out the core targets according to the degree value, and performed GO enrichment analysis and KEGG pathway analysis through the DAVID database. Results 875 and 952 targets related to osteoporosis and non-alcoholic fatty liver were screened by searching the related disease database. 217 key targets were mapped out, and 24 core targets were screened out with degree≥36. Imported DAVID database to obtain 78 GO enrichment results (P<0.05) and 78 KEGG signal pathways (P<0.05). Conclusion IL6, INS, VEGFA, AKT1 and other core targets act on the hepatitis B pathway, rheumatoid arthritis pathway, TNF pathway, IBD pathway to regulate inflammatory response and glucose and lipid metabolism and other biological processes, so that osteoporosis and non-alcoholic fatty liver can interact with each other. The impact provides a more scientific theoretical basis for the clinical treatment of the two diseases. |