| Pregnancy and lactation-associated osteoporosis (Pregnancy and lactation-associated osteoporosis, PLO) is a rare clinically specific osteoporosis. Most cases appear in the late pregnancy or early postpartum of the primipara, but it also occurs in After the parturient. PLO patients mainly present with severe lower back pain, height loss, and fragility fractures, especially vertebral fractures, in the late pregnancy and early postpartum. So far, the global reported prevalence of PLO patients is only more than 120 cases. There is still a lack of guidelines and consensus on the treatment of PLO. In each reported case, it is pointed out that supplementation of bisphosphonates, calcium and vitamin D is the first-line therapy for the treatment of PLO. In addition, teriparatide, strontium ranelate, and desulimab are also used Proved to help increase bone density (Bone density, BMD).Here we retrospectively analyze the clinical data of two patients with PLO and review relevant literature to improve the understanding of PLO disease. |