| Objective To explore the mechanism of ZJP in the treatment of diabetic osteoporosis by means of network pharmacology and molecular docking. Methods Firstly, the active components and targets of ZJP were retrieved from TCMSP and BATMAN-TCM databases respectively, the related targets of DOP were retrieved from GeneCards and OMIM databases, and the DOP targets of ZJP were obtained by Venny system. Then, the protein interaction network was constructed by String database. Cytoscape software was used to obtain the "active component-target" network diagram, and the CxtoNCA was used to obtain the key targets of the network. Next, GO function and KEGG enrichment analysis of genes were performed by DAVID database. Finally, PubChem database, PDB database and ChemOffice software, molecular docking was performed to analyze the binding activity. Results There were 236 main active components, 5 key active components, 151 DOP targets of ZJP, 16 core targets, 66 GO enrichment items, 104 KEGG pathway enrichment items in ZIP, and good molecular docking. Conclusion The active compounds Quercetin, kaempferol, luteolin and β-sitosterol in ZJP may act on involving targets could regulate Fluid shear stress and atherosclerosis, TNF signaling pathway, AGE-RAGE signaling pathway in diabetic complications, Wnt/β-catenin and RANKL/RANK signaling pathway to promote the proliferation and differentiation of osteoblasts, promote apoptosis of osteoclasts, inhibit the generation of osteoclasts for achieving the effect of DOP treatment. |