| Knee osteoarthritis and osteoporosis are degenerative diseases of bone and joint associated with increasing age. Both of them have common features in pathogenesis, pathological changes, regulatory mechanism and clinical treatment. In the process of knee osteoarthritis and osteoporosis, complex regulatory mechanisms are used to maintain the balance of bone metabolism, reduce inflammation, protect articular cartilage, stabilize the knee joint, and then delay the degeneration of the knee joint. Although the complex regulatory mechanisms between the two have been studied, they are still imperfect. In this study, we reviewed the regulatory mechanisms of knee osteoarthritis with osteoporosis from the aspects of inflammation, biomechanics, hormone and bone metabolism, genetics, and protein in order to provide new ideas and theoretical basis for clinical prevention and treatment of the disease. |