| Chronic obstructive pulmonary disease (COPD) and osteoporosis are common in the elderly, and there is a co-disease relationship between them, which can affect each other through a variety of mechanisms to reduce the quality of life of patients. Bone strength includes bone mineral density and bone quality, bone mineral density is currently the gold standard for the diagnosis of osteoporosis, accounting for 70% of bone strength, but bone quality also plays an important role in the process of osteoporosis and fracture in patients with COPD. The effect of COPD on bone strength is comprehensive in many aspects, such as body mass index, exercise tolerance, vitamin D deficiency, systemic inflammation, using corticosteroid and so on. It affects bone mineral density and bone quality through a variety of molecular signal regulation pathways, reduces bone strength and increases the risk of fracture. Clinically, patients with COPD should be improved in bone strength on multiple levels, including bone mineral density and bone quality, to actively prevent and treat the risk of osteoporosis and fracture. |