| Bone turnover markers are biochemical products that reflect the activity of bone cells and the metabolic level of bone matrix. They are biochemical markers released in the blood or urine during the process of bone reconstruction, and they reflect the dynamic changes of bone tissue in the whole body earlier than bone mineral density. They have the characteristics of good sensitivity, high specificity, good reproducibility, non-invasive, and economical and applicable, and have become an important index for the diagnosis of metabolic bone disease, evaluation of therapeutic response, and prediction of fracture risk. So far, bone turnover markers，such as BALP, P1NP, and CTX, have been widely applied in the clinical work. Some novel bone turnover markers, including CXC, GSN, and ANXA2, have been studied aboard, but the study in our country is less. In order to confirm whether they are suitable for effective indicators to reflect the dynamic changes of bone turnover, we review the research progress in these markers. |