| Objective To investigate the characteristics of bone metabolism in patients with glucocorticoid-induced osteoporosis (GIOP), and to provide evidence for the differential diagnosis of secondary osteoporosis and drug selection for GIOP treatment. Methods This study is a retrospective study. We selected 88 patients who visited our hospital from June 2019 to June 2021 as the research objects, who were divided into the GIOP group (48 cases) and the normal control group (40 cases). The general clinical data, biochemical indexes of bone metabolism, calcium-regulating hormones and bone mineral density were collected from the two groups. The difference of each index between the two groups was analyzed for statistical significance, and the correlation between each index was calculated. Results The level of total type I collagen amino acid extension peptide (tPINP) in the GIOP group was significantly lower than that in the normal control group., and there was a significant difference. In the GIOP group, Pearson's correlation analysis showed that tPINP was positively correlated with CTX (r=0.509, P＜0.01), OG (r=0.750, P＜0.01), and P (r=0.294, P＜0.05), respectively; OG was positively correlated with CTX (r=0.524, P＜0.01), P (r=0.403, P＜0.01), respectively; PTH was negatively correlated with P (r=-0.439, P<0.01). Conclusion The reduction of bone formation may be one of the important pathogenesis of GIOP. Selecting drugs that promote osteoblast activity or anti-osteoblast apoptosis may improve the efficacy of patients with GIOP. |