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| 非编码RNA在骨质疏松症预测和防治中的作用研究进展 |
| Research progress on the role of non-coding RNA in the prediction and prevention of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2022.06.019 |
| 中文关键词: 非编码RNA 骨质疏松症 骨代谢 骨形成 骨吸收 生物标志物 |
| 英文关键词:non-coding RNA osteoporosis bone metabolism bone formation bone resorption biomarkers |
| 基金项目:国家自然科学基金项目(82072423) |
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| 中文摘要: |
| 骨质疏松症（osteoporosis，OP）严重影响着中老年人群的生活质量，因此OP患病前的有效预测和患病后安全有效的治疗措施极为重要。研究发现非编码RNA（non-coding RNAs，ncRNAs）作为表观遗传调节剂与骨代谢关系密切，能够在基因层面调控OP的发生发展，可作为OP预测、诊断的生物标志物和治疗的新靶点。非编码RNA的功能及表达水平异常可导致骨形成和骨吸收平衡失调，引起OP。本文将重点介绍4种常见非编码RNA（circRNA、lncRNA、miRNA和siRNA）的作用机制以及对骨代谢过程中骨形成和骨吸收的影响，旨在为OP的诊断和防治提供理论依据。 |
| 英文摘要: |
| Osteoporosis (OP) seriously affects the quality of life of middle-aged and elderly people, so it is very important to predict the occurrence reliably and find some effective treatments of the OP. It has been found that non-coding RNA (ncRNAs), as epigenetic regulators, is closely related to bone metabolism, which can regulate the occurrence and development of OP at the gene level. In the meantime, non-coding RNA can be used as a biomarker to predict and diagnose the OP and as a new treatment target for OP. Abnormal function and expression of non-coding RNA can cause imbalance between bone formation and bone absorption, which can lead to osteoporosis. This paper focuses on the mechanism of four common non-coding RNAs (circRNA, lncRNA, miRNA and siRNA) and their effects on bone formation and bone resorption in the process of bone metabolism, in order to provide a theoretical basis for the diagnosis and prevention of OP. |
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