| Osteoporosis often results in fracture, with the high disability and mortality, and seriously affects the patients’ life quality. Radix Rehmannia and its formulating prescription have significant anti-osteoporosis effects, and in this regard, more and more studies have found and reported the effects and mechanisms of catalpol, the active component of Radix Rehmannia, and the certain research outputs have been achieved. This article searched the Pubmed, Web of science, China National Knowledge Infrastructure, and Wanfang database for the recent 10 years related literature, collected and organized the latest anti-osteoporosis progress of catalpol. We summarized the in-vivo anti-osteoporosis effects of catalpol on skull defect models, ovariectomy models and diabetic osteoporosis models, and the in-vitro anti-osteoporosis effects on bone marrow mesenchyml stem cells, osteoblasts and osteoclasts, analyzed the research dynamic, administration dosage, and function indexes and mechanisms such as Wnt, Hedgehog and PTEN/RANKL to excavate the potential targets and signaling pathways for providing the reference on studying the mechanism and playing better anti-osteoporosis roles of Radix Rehmannia and catalpol. |