| Idiopathic juvenile osteoporosis (IJO) is a rare and self-limited systemic bone disease characterized by systemic bone pain, fractures, and difficulty walking in early adolescence, which spontaneously resolves in most patients as puberty develops. The etiology of the disease remains unknown. The imaging manifestations show a decrease in bone mineral density in the whole body, and fractures in the lumbar vertebra and long bones, especially in the metaphyseal region. The osteoporosis in new bones is its unique imaging manifestations. The diagnosis is based on the exclusion of other common causes of adolescent osteoporosis. At present, there is no consensus on the drug therapy standard. Supplement of calcium and vitamin D and the use of bisphosphonates are the main treatment measure. The majority of patients have a good prognosis, but a few are left with severe disability. This article reviews the recent advances in the pathogenesis, clinical manifestations, imaging features, diagnosis, and treatment of IJO. |