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| 可变剪接与成骨分化的研究进展 |
| Research progress in alternative splicing in osteogenic differentiation |
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| DOI：10.3969/j.issn.1006-7108.2022.06.027 |
| 中文关键词: 可变剪接 成骨分化 转录因子 |
| 英文关键词:alternative splicing osteogenic differentiation transcription factors |
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| 中文摘要: |
| 间充质干细胞（mesenchymal stem cells，MSCs)的成骨分化在骨相关疾病的治疗中具有潜在的临床价值。可变剪接（alternative splicing，AS）常以组织或时间特异性的方式发生，在组织发育和疾病中起着重要的作用，是高等真核生物蛋白质多样性的主要来源之一。成骨细胞分化是一个多步骤有序发生的过程，涉及一系列转录因子的协同表达。AS在调节成骨细胞功能和骨形成的过程中发挥着关键作用。成骨分化过程中超过120余种基因发生AS，包括RUNX2、Sp7、Vegf-A和FosB等。该综述详细总结了成骨分化过程中发生AS的关键转录因子，以及所产生的各剪接体在成骨分化分子遗传网络中的不同作用。 |
| 英文摘要: |
| The osteogenic differentiation of mesenchymal stem cells (MSCs) has potential clinical values in the treatment of bone-related diseases. Alternative splicing (AS) frequently occurs in a tissue- or time-specific manner and plays a significant role in tissue development and diseases, contributing to the majority of protein diversity in higher eukaryotes. Osteogenic differentiation is a multi-step process involving in the co-expression of a series of transcription factors. AS plays a pivotal role in osteoblastic function and bone formation. More than 120 genes develop AS in osteogenic differentiation, including Runx2, SP7, VEGF-A, and FosB. In this review, we summarize in detail about the key transcription factors regulated by AS and splicing subtypes generated that play a different role in molecular genetic network of osteogenic differentiation. |
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