Objective To investigate the relationship between serum uric acid (SUA) level and low skeletal muscle mass in patients with type 2 diabetes. Methods A cross-sectional study was used to select 2120 patients with type 2 diabetes admitted to the Department of Endocrinology, Changzhou Second People's Hospital, Affiliated Hospital of Nanjing Medical University from January 2017 to December 2019. The appendicular skeletal muscle relative mass index (ASMI) was evaluated using biological resistance measurement. According to the diagnostic criteria of the Asian Sarcopenia Working Group, the study subjects were divided into two groups, the low ASMI group (n=366) and the normal ASMI group (n=1754). Age, gender, diabetes duration, body mass index (BMI), SUA, and other blood index were collected. The differences between the two groups were analyzed using t test. The correlation between ASMI and different indexes was analyzed using Pearson correlation analysis. Multivariate linear regression and logistic regression analysis were used to find out the impact of serum uric acid level on ASMI. Results BMI and SUA were significantly lower in the low ASMI group, while age was significantly higher in the low ASMI group than those in the normal ASMI group. ASMI was positively correlated with SUA and BMI, negatively with age. Multiple linear regression analysis showed that after adjusting for age and BMI, there was still a positive correlation between serum uric acid and ASMI. Binary logistic regression analysis showed that the risk of low ASMI decreased by 0.5 percent for every 1mmol/L increase in serum uric acid after adjusting for age. Conclusion The increase of SUA may be a protective factor for skeletal muscle loss in patients with type 2 diabetes. |