中国骨质疏松杂志

热敏灸治疗原发性骨质疏松症的系统评价与Meta分析

Efficacy of heat sensitive moxibustion for primary osteoporosis: A systematic review and Meta analysis

DOI：10.3969/j.issn.1006-7108.2022.08.004

英文关键词:heat sensitive moxibustion primary osteoporosis systematic review Meta analysis

基金项目:国家自然科学基金（81973889)；2019年度服务地方科学研究计划(19JC013)

作者	单位
陶林1.2.3 张磊1.2.3 李姣1.2.3 王可欣1 .3 杨锋1.2.3*	1.???? 陕西中医药大学，陕西咸阳 712046 2.?? 陕西高校青年创新团队，陕西咸阳 712046 3. 陕西中医药大学附属医院，陕西咸阳 712000

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中文摘要:

摘要：目的运用循证医学方法评价热敏灸治疗原发性骨质疏松症（primary osteoporosis，POP）疗效。方法从CNKI、VIP、Wanfang、SinoMed和Pubmed数据库检索热敏灸治疗POP的随机对照试验，时间为建库至2021年8月。2名研究者依据纳入和排除标准独立筛选文献、提取资料。使用Cochrane系统评价手册5.1.0版评价文献偏倚风险并用RevMan5.3软件绘图，以Stata16软件进行合并分析并绘制森林图。结果共纳入14项研究，受试者共921例。Meta分析结果显示，总有效率：OR=1.48，95 % CI (0.95，2.01)，P< 0.01；骨密度(BMD)：MD =0.05，95% CI (0.02，0.07)，P< 0.01；视觉模拟评分(VAS)：[MD = –1.13，95% CI (–1.49，–0.76)，P< 0.01；生活质量量表（SF-36）总评分：MD =–1.55，95% CI (–6.76，9.81)，P=0.71；骨保护素(OPG)：MD =49.73，95% CI (22.81，76.65)，P< 0.01；Ⅰ型胶原羧基末端肽（CTX）：MD =–0.18，95% CI (–0.22，–0.14)，P<0.01；Ⅰ型胶原氨基末端肽（NTX）：MD =–0.66，95% CI (–0.86，–0.47)，P<0.01。结论热敏灸治疗POP能够使BMD有所增加，改善POP骨痛，改善OPG、CTX以及NTX等骨代谢指标。本研究纳入文献质量不高，治疗效果证据较为有限，尚需更多大样本、多中心、高质量临床随机对照研究予以佐证。

英文摘要:

Abstract: Objective Evidence based methods were used to evaluate the efficacy of heat sensitive moxibustion for Primary Osteoporosis(POP). Methods A randomized controlled trial (RCT) of heat sensitive moxibustion for POP was retrieved from CNKI, VIP, Sinomed, Wanfang, and PubMed until August 2021. Then, the literature was screened, extracted, crosschecked independently by 2 researchers according to the inclusion and exclusion criteria, and the quality of the literature was assessed using the Cochrane Handbook for systematic reviews and a graph of the literature quality was produced using revman 5.3 software, with Stata 16 software for Meta-analysis. Results A total of 14 studies with 921 participants were included in the Meta-analysis: effective rate [OR=1.48，95%CI(0.95，2.01), P<0.01]; BMD[MD=0.05, 95%CI(0.02, 0.07), P<0.01]; VAS[MD=–1.13, 95%CI(–1.49, –0.76), P<0.01], SF-36 score[MD=–1.55, 95%CI(–6.76, 9.81), P=0.71], OPG[MD = 49.73, 95% CI (22.81, 76.65), P < 0.01], CTX [MD =–0.18, 95% CI (–0.22, –0.14), P < 0.01], NTX[MD =–0.66, 95% CI (–0.86, –0.47), P < 0.01]. Conclusion Heat sensitive moxibustion for POP can slightly increase the value of BMD, improve osteoporotic bone pain and improve bone metabolism. The quality of literature included in this study was not high, and the evidence of treatment effect was limited, so more large sample, multicenter, high-quality clinical randomized controlled studies are still needed for evidence.

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