Abstract: Objective To analyze the correlation between ACPAs antibodies (mainly AMCV and ACCP) and osteoporosis secondary to rheumatoid arthritis, as well as bone mineral density and bone metabolism indicators. Methods According to the inclusion criteria and exclusion criteria, 591 RA patients from the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology were selected. The clinical data of the patients were recorded in detail. ELISA method was used to detect AMCV, ACCP, three subtypes of RF, and bone metabolism indicators PINP, β-CTX, N-MID OC, and 25HVD. DXA was used to detect BMD, BMC, Z value, and T value of the hip and lumbar spine of RA patients. Statistical analysis was performed with a SPSS 20 software. Results The AMCV and ACCP positive group had higher levels of IgA, IgM, three subtypes of RF than the negative group, but 25HVD was reversed. PINP and N-MID OC were positively correlated with the course of the disease, but bone mineral density indexes were negatively correlated with the course of the disease. 25HVD was negatively correlated with ACCP, AMCV, and the three subtypes of RF. The levels of PINP and N-MID OC increased with the increase of the disease course. The levels of 25HVD and bone mineral density index decreased with the increase of the disease course. Compared with those in the normal bone mass group and the osteopenic group, the patients in osteoporosis group were older, with longer disease course, and higher RF levels of the three subtypes. Conclusion ACPAs antibodies were negatively correlated with 25HVD in RA patients. Bone mineral density and bone metabolism in RA patients were negatively correlated with the course of the disease. RA patients with secondary osteoporosis have more complicated condition. |