Abstract:Objective To observe the clinical study of Yougui pill onPostmenopausal osteopenia with kidney yang deficiency. Methods A total of 81 postmenopausal patients with osteopenia and kidney-yang deficiency who were treated in shaanxi university of traditional Chinese medicine hospital rehabilitation medicine from October 2020 to June 2021 were selected, who were divided into the treatment group (n=40) and the control group (n=41) through the random number method.The control group was given calcium carbonate and vitamin D3 tablets orally and warm acupuncture, while the treatment group was given Yougui Pill on the basis of the control group. The total course of treatment was 12 weeks. The total response rate of the treatment group and the control group after treatment, Changes of bone metabolic markers [serum osteocalcin (BGP), 25-hydroxyvitamin D3, β -collagen degradation product (β-CTX), type Ⅰ procollagen amino-terminal propeptide (PINP)], sex hormones [luteinizing hormone (LH), serum estradiol (E2), follicle-stimulating hormone (FSH)], bone density of left hip joint and L1-4 before and after treatment Degree (BMD), TCM syndrome score, total physical health score of Quality of Life Scale (PCS) and adverse reaction rate. Results After treatment, the total effective rate of control group and treatment group was 71.05 % and 86.84 %, respectively (P<0.05). After treatment, the levels of bone metabolism markers and TCM syndrome scores in 2 groups were significantly lower than before, and the levels in treatment group were significantly lower than that in control group (P<0.05). After treatment, the levels of BMD, LH, E2, FSH and PCS score in 2 groups were significantly increased compared with before treatment, and the treatment group was significantly higher than the control group (P<0.05). The incidence of adverse reactions in the treatment group was 7.89 % (3/38) and 5.26 % (2/38) in the control group (P>0.05). Conclusion Yougui pill has a good curative effect in the treatment of postmenopausal patients with reduced bone mass due to kidney Yang deficiency, which reduces TCM syndrome score, increases bone mineral density, regulates bone metabolism, improves PCS score, and improves quality of life. With fewer adverse reactions, yougui Pill is worthy of clinical promotion. |