| Abstract: In recent years, bone defect due to malignant tumor resection, trauma, and teeth trauma is common in clinics. In addition, because of the improvement of the quality of life and diet structure change to high quantity of heat, high fat, and high purine food, the prevalence and incidence of diabetes, cerebrovascular disease, obesity, hyperlipidemia increased year by year. Eventually, changes in bone mineral density and bone metabolism occur and metabolic bone disease increases. Therefore, bone repair and regulating bone metabolism has become an important research direction. The methods to induce bone formation, such as parathyroid hormone therapy, bisphosphonates, and romosozumab, also have side effects, such as tumor growth, hypercalcemia, and jaw bone osteonecrosis. With the deepening of studies on induced bone formation, more and more researchers are paying attention to the relationship between bone morphoproteins (BMPs) and bone regeneration. Based on relevant literature, this paper focuses on the clinical application of some bone morphoproteins, in order to provide new ideas and methods for the treatment of bone defects and metabolic bone diseases. |