| Objective To investigate risk factors of rheumatoid arthritis (RA) combined with osteoporosis (OP) by analysis of bone mineral density (BMD) and related clinical factors in 1061 patients with RA. Methods A total of 1061 RA patients diagnosed in our hospital from January 2016 to August 2020 were selected and 636 healthy subjects were examined during the same period. BMD of the lumbar spine 1 to 4 and left proximal femur were detected with dual-energy X-ray. RF, erythrocyte sedimentation rate, C-reactive protein, and anti-CCP antibody were detected. General data of RA patients were collected. Results BMD of the femoral neck, femoral trochanter, intertrochanter, total hip joint, 1 to 4 lumbar spine, and all lumbar vertebra in RA group were lower (P<0.001), and the proportion of low bone mass and osteoporosis were 36.5% and 30.7% higher (P<0.001), respectively, than those in the control group. RA was an independent risk factor for OP and the OR value was 2.30 (1.70-3.09). BMI was a protective factor for RA combined with OP and the OR value was 0.82 (0.77-0.86). Age, female, glucocorticoid use for more than 1 month, history of fragility fracture, and necrosis of femoral head were independent risk factors for RA combined with OP, with?OR values of 1.14 (1.12-1.16), 4.83 (3.05-7.64), 2.31 (1.57-3.41), 6.90(2.28-20.88), and 16.19(3.20-81.90), respectively.?Anti-CCP antibody, RF, and DAS28 scores were not risk factors of RA combined with OP. Conclusion BMD in RA patients is significantly lower than that in healthy people. The risk of OP in RA patients increases. It is especially necessary to pay attention to the occurrence of osteoporosis in patients with elder age, female gender, long course of disease, low body weight, fragility fracture history, femoral head necrosis, and the use of glucocorticoids. |