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| 白藜芦醇在骨关节炎中的作用及机制研究进展 |
| Research progress on the role and mechanism of resveratrol in osteoarthritis |
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| DOI：10.3969/j.issn.1006.7108.2022.09.018 |
| 中文关键词: 骨关节炎 白藜芦醇 软骨退化 信号通路 机制研究 |
| 英文关键词:osteoarthritis resveratrol cartilage degeneration signaling pathway mechanism research |
| 基金项目:国家自然科学基金（82102568；82102076；82172432；82001319）；广东省基础与应用基础研究基金（2021A1515012586；2019A1515110983；2019A1515011290）；白求恩·石药骨质疏松科研基金项目（G-X-2020-1107-21）；北京大学深圳医院科研启动金项目（KYQD2021099） |
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| 中文摘要: |
| 骨关节炎（osteoarthritis, OA）是由衰老、肥胖、创伤、遗传等多因素引起的慢性退行性疾病，是临床上骨科医生面临的棘手疾病，该病给患者及其家庭带来了沉重的负担。白藜芦醇是一种具有抗炎、抗氧化等作用的天然化合物，可通过影响软骨衰老、软骨基质代谢、软骨损伤等作用参与OA的发生发展进程，这一过程可能与核因子-κB（NF-κB）、Toll样受体4（TLR4）、细胞外信号调节激酶（ERK）等信号通路的调控有关。本文拟就白藜芦醇在OA进程中的作用及其可能机制的研究进展作一综述，以期为相关研究提供参考。 |
| 英文摘要: |
| Osteoarthritis (OA) is a chronic degenerative disease caused by aging, obesity, trauma, heredity and other factors, which is a difficult disease faced by orthopedic doctors in clinic, and brings a heavy burden to patients and families. Resveratrol is a natural compound with anti-inflammatory and antioxidant effects. It can affect cartilage aging, cartilage matrix metabolism, and cartilage injury in participate in the process of OA, which might be related to NF-κB, TLR4 and ERK signaling pathway. This paper reviews the research progress of resveratrol in the process of OA and its possible mechanism, so as to facilitate relevant research. |
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