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| 肌少症造模方法的研究进展 |
| Research progress in modeling methods of sarcopenia |
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| DOI：10.3969/j.issn.1006.7108.2022.09.021 |
| 中文关键词: 肌少症 造模方法 发病机制 研究进展 |
| 英文关键词:sarcopenia mold making method pathogenesis research progress |
| 基金项目:上海市科学技术委员会项目（19401901100;21S21900500）；上海中医药大学附属龙华医院第五批龙医学者（KC2022006）；国家中医药管理局中医药特色技术传承专项（GZY-KJS-2020-083）；上海卫生健康委员会海派中医流派传承创新团队（2021LPTD-008） |
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| 中文摘要: |
| 肌少症以肌肉质量减少、力量减退、功能下降为主要表现，可增加跌倒和骨折风险，是老年人的常见病和多发病。随着人口老龄化程度的不断加剧，肌少症所带来的问题逐渐突显。明确本病的发病机制至关重要，现有的肌少症造模方案各有利弊，造模时间短、成本低、与人类肌少症病理改变高度一致的动物模型是研究的关键步骤。故查阅近年来国内外文献，总结并探讨肌少症造模方法的研究进展，以期为肌少症的研究提供参考。 |
| 英文摘要: |
| Sarcopenia is a common disease and frequently occurring disease in the elderly. The main manifestations of sarcopenia are loss of muscle mass, strength and function, which can increase the risk of falls and fractures.With the aggravation of aging society, sarcopenia brings more and more serious problems.?Exploring and clarifying the pathogenesis of sarcopenia has become a current research focus. At present, the modeling of sarcopenia has both advantages and disadvantages, An animal model with short modeling time, low cost and a high degree of consistency with human sarcopenia is a key step in the research.?Therefore, the domestic and foreign literature in recent years was reviewed to summarize and discuss the research progress of sarcopenia modeling methods, in order to provide reference for sarcopenia modeling. |
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