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| Wnt5a基因在骨关节炎中作用机制的研究进展 |
| Research progress in the mechanism of Wnt5a gene in osteoarthritis |
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| DOI：10.3969/j.issn.1006.7108.2022.10.021 |
| 中文关键词: Wnt5a基因 骨关节炎 Wnt通路 作用机制 |
| 英文关键词:Wnt5a gene osteoarthritis Wnt signaling pathway mechanism research |
| 基金项目:国家自然科学基金（82102568，82102076，82172432，82001319）；广东省基础与应用基础研究基金（2021A1515012586，2019A1515110983，2019A1515011290）；白求恩·石药骨质疏松科研基金项目（G-X-2020-1107-21）；北京大学深圳医院科研启动金项目（KYQD2021099） |
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| 中文摘要: |
| 骨关节炎（osteoarthritis, OA）是由于关节软骨退变丢失导致的一种临床常见慢性退行性疾病，给患者及国家带来沉重医疗负担，对其机制深入研究有利于临床加强对OA的治疗。近年研究发现，无翅型MMTV整合位点家族成员5A（Wnt5a）基因在OA的发病及进展中有重要作用，其可以影响OA的独立发病因素如衰老、代谢所致肥胖、创伤等参与OA的发病，并可以通过经典（Wnt/β-catenin）及非经典（Wnt/Ca2+和Wnt/Planar polarity等）Wnt通路参与OA的调控。本文就Wnt5a基因在OA中的作用及机制作一综述，为相关研究提供便利。 |
| 英文摘要: |
| Osteoarthritis (OA) is a common clinical chronic degenerative disease caused by the degeneration and loss of articular cartilage, which brings a heavy medical burden to patients and the country. The in-depth study of its mechanism is conducive to strengthen the treatment of OA. Recent studies have found that wingless type MMTV integration site family member 5A (Wnt5a) gene plays an important role in the pathogenesis and progress of OA. It can affect the independent pathogenesis of OA, such as aging, metabolic obesity, and trauma, and can participate in it through classical and non-classical Wnt signaling pathways. This paper reviews the role and mechanism of Wnt5a gene in OA, so as to provide benefit for related research. |
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