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| 高糖对骨髓间充质干细胞作用机制的研究进展 |
| Research progress on the mechanism of high glucose on bone marrow mesenchymal stem cells |
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| DOI：10.3969/j.issn.1006.7108.2022.10.027 |
| 中文关键词: 高糖 骨髓间充质干细胞 糖尿病性骨质疏松症 |
| 英文关键词:high glucose bone marrow mesenchymal stem cells diabetic osteoporosis |
| 基金项目:江苏省级重点研发计划（社会发展）项目（骨靶向性凝胶缓释系统的构建和抗骨质疏松作用验证）（BE2019653）；江苏省研究生实践创新计划（基于不同信号通路 cross-talk 研究骨碎补总黄酮防治DOP机制）（SJCX21_0804） |
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| 中文摘要: |
| 骨髓间充质干细胞的功能改变与功能障碍是糖尿病性骨质疏松病态骨代谢模式的根本原因。在长期高糖环境下，骨髓间充质干细胞生物活性及功能特性发生紊乱。具体表现为：高糖会促进骨髓间充质干细胞的凋亡、自噬、铁死亡及成脂向分化，抑制其旁分泌及成血管向分化，但在细胞增殖、定向迁移及成骨向分化方面仍存在一定争议。因此，深入研究高糖对骨髓间充质干细胞的作用机制，有利于突破糖尿病性骨质疏松症干细胞疗法的局限性，挖掘潜能优势。 |
| 英文摘要: |
| The functional changes and dysfunction of bone marrow mesenchymal stem cells are the underlying cause of the pathological bone metabolism pattern of diabetic osteoporosis. In the long-term high glucose environment, the biological activity and functional characteristics of bone marrow mesenchymal stem cells are disordered. Specifically, high glucose promotes the apoptosis, autophagy, iron death, and adipogenic differentiation of bone marrow mesenchymal stem cells, and inhibits their paracrine and angiogenic differentiation. However, there are still some disputes on cell proliferation, directional migration, and osteogenic differentiation. Therefore, in-depth study of the mechanism of high glucose on bone marrow mesenchymal stem cells is conducive to break through the limitations of stem cell therapy for diabetic osteoporosis and to explore the potential advantages. |
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