| Wnt/GSK-3β/β-catenin pathway is a widely acting classical signaling pathway that plays an important role in various processes such as bone growth and development and bone marrow stem cell transformation. In this paper, we studied the literature on the effects of different traditional Chinese medicines on bone remodeling through this pathway, and learned that single herbs such as bitter herbs Duhuo, Veratrum, Curcuma longa, Coptis chinensis, and Scutellaria baicalensis, tonifying kidney drugs Tortoise Plate, Herba Epimedii, Rhizoma Drynariae, invigorating qi drugs Astragalus membranaceus, and tonifying kidney Chinese medicine compounds such as Zuogui pills, Yougui pills, and Jingui Shenqi pills inhibited the expression of GSK-3β by regulating the Wnt/GSK-3β/β-catenin pathway, promoted more β-catenin to transfer into the nucleus, and then induced bone marrow stem cells to differentiate into osteoblasts and inhibited bone fragmentation, in order to achieve the effects of increasing bone mineral density. By observing the effect of traditional Chinese medicine on the expression of various proteins of Wnt/GSK-3β/β-catenin pathway, the regulatory effect of traditional Chinese medicine on bone metabolism was elucidated, providing ideas for the research and development of traditional Chinese medicine compound in the treatment of osteoporosis. |