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| 骨骼对中枢神经系统调控作用的研究进展 |
| Research progress about the regulatory effects of skeleton on the central nervous system |
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| DOI：10.3969/j.issn.1006-7108.2022.11.021 |
| 中文关键词: 骨 中枢神经系统 骨源性因子 骨源性细胞 |
| 英文关键词:skeleton central nervous system bone-derived factors bone-derived cells |
| 基金项目:科技部重点研发计划（2018YFC1704302）；国家自然科学基金（82074468,81930116）；上海市优秀学术带头人计划（19XD1423800）；科技部重点领域创新团队计划项目（2015RA4002） |
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| 中文摘要: |
| 骨骼一直被认为是惰性器官。近年来，研究发现骨骼作为一个重要的内分泌组织，通过感知和整合不同刺激，向中枢神经系统发送信号。骨骼影响中枢系统功能的机制，可能是通过分泌骨源性因子（骨钙素、骨硬化蛋白、Dickkopf相关蛋白1、脂质运载蛋白2、成纤维细胞生长因子23），或者通过骨源性细胞（骨髓间充质干细胞、骨髓来源的小胶质样细胞）的生物调控。本文对以上骨骼影响中枢神经系统生物学作用的潜在机制进行初步探讨，为防治中枢神经系统疾病提供新方向。 |
| 英文摘要: |
| Skeleton is considered to be an inert organ for many years. In recent years, it was found that skeleton, as one of vital endocrine tissues, could send signals to central nervous system (CNS) via sensing and integrating kinds of stimuli. The mechanisms involved in the affections of skeleton on the function of CNS partially are attributed to the bone-derived factors (osteocalcin, sclerostin, Dickkopf-related protein-1, lipocalin 2, and fibroblast growth factor 23), or bone-derived cells (bone marrow mesenchymal stem cells and bone marrow-derived microglia-like cells). This review preliminarily discussed the above-mentioned potential mechanisms, so as to provide the novel direction for the prevention and treatment of CNS diseases. |
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