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| TLR4/MyD88信号通路在膝骨关节炎滑膜炎中的作用 |
| The role of TLR4/MyD88 signaling pathway in synovitis of knee osteoarthritis |
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| DOI：10.3969/j.issn.1006-7108.2022.11.025 |
| 中文关键词: TLR4 MyD88 膝骨关节炎滑膜炎 |
| 英文关键词:TLR4 MyD88 synovitis of knee osteoarthritis |
| 基金项目:国家自然科学基金地区项目（82060873）；甘肃中医药大学附属医院青年基金项目（921y-2019-08）；甘肃中医药大学中青年科研基金项目（2305016601） |
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| 中文摘要: |
| Toll样受体4是重要的固有免疫模式识别受体，通过识别损伤相关分子模式及病原相关分子模式，启动髓样分化因子 88依赖途径后激活NF-κB信号通路，引发炎性介质及细胞因子的分泌，触发固有免疫应答，在膝骨关节炎滑膜炎的发生中发挥作用。研究TLR4/MyD88信号通路在膝骨关节炎滑膜炎中的作用，以期更深入的阐明膝骨关节炎滑膜炎发病机制，为膝骨关节炎滑膜炎的诊疗提供理论依据和参考。 |
| 英文摘要: |
| Toll-like receptor 4 is an important innate immune pattern recognition receptor. It activates NF-κB signaling pathway by triggering myeloid differentiation factor 88-dependent pathway after identifying damage related molecular patterns and pathogen related molecular patterns, and lead to the secretion of inflammatory mediators and cytokines. It triggers innate immune response, and playing a role in the occurrence of synovitis in knee osteoarthritis. Study the role of TLR4/MyD88 signaling pathway in synovitis of knee osteoarthritis, can clarify the pathogenesis about synovitis of knee osteoarthritis and provide theoretical basis and reference for the diagnosis and treatment on synovitis of knee osteoarthritis. |
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