| Objective A retrospective research was designed to analyze the relationship between serum uric acid to creatinine ratio (SUA/CR) and bone turnover markers, bone mineral density (BMD) in middle-aging males and postmenopausal females with type 2 diabetes mellitus (T2DM). Methods We recruited 333 male and 335 female patients with T2DM and assigned them into 3 groups according to the level of SUA/CR respectively. Males were divided into M1, M2, and M3 group. Females were divided into F1, F2, and F3 group. Results (1) The higher the SUA/CR levels, the lower the proportion of osteoporosis or osteopenia presented in middle-aging males and postmenopausal females. (2) In middle-aging males, BMD of the femoral neck was the lowest in M1 group, and n-mid osteocalcin (N-OC) and c-terminal crosslinking peptide of type 1 collagen (CTX) were the highest in M1 group (P < 0.05). In postmenopausal females, the BMD of lumbar 1-4, femoral neck, Ward's triangle and great trochanter were the highest in F3 group (P < 0.05). The highest levels of N-OC and CTX levels were in F2 group (P < 0.05). (3) Pearson correlation analyses revealed that SUA/CR was significantly and positively associated with BMD of the femoral neck and negatively associated with N-OC, CTX, and P1NP in middle-aging male patients (P < 0.05). SUA/CR was significantly and positively associated with BMD and VD of the femoral neck, lumbar L1-4, Ward's triangle, and great trochanter and negatively associated with N-OC, CTX, and P1NP in postmenopausal patients. (4) Logistic regression analysis indicated that SUA/CR was a protective factor for osteoporosis and osteopenia in middle-aging males and postmenopausal patients with T2DM. Conclusion High SUA/CR level is a protective factor for osteoporosis and osteopenia in middle-aging males and postmenopausal females with T2DM. |