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| IL-17诱导骨质疏松症的作用机制分析 |
| Mechanism analysis of IL-17 induced osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2023.12.024 |
| 中文关键词: IL-17 骨质疏松 免疫系统 作用机制 |
| 英文关键词:IL-17 osteoporosis immune system mechanism of action |
| 基金项目:广东省中医药局科研项目（20221146）；广东省基础与应用基础研究基金项目（2020A1515110948）；广州市科技计划项目（202102021040）；广州中医药大学第一附属医院高水平医院建设项目（2019IIT32） |
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| 中文摘要: |
| “免疫-骨质疏松症”联合研究是免疫系统在骨质疏松症（osteoporosis，OP）中作用机制的一个新兴研究领域。白细胞介素-17(interleukin-17，IL-17)是一种由活化的免疫T淋巴细胞17（T lymphocytes 17，Th17）分泌的炎性因子。现代研究显示，IL-17通过作用于相关蛋白、基因、信号通路等多个有效途径，抑制间充质干细胞（mesenchymal stem cell，MSCs）成骨分化、抑制成骨细胞(osteoblast，OB)分化及其相关功能、促进破骨细胞（osteoclast，OC）分化及其功能的效果，最终影响OP的进展。笔者通过对IL-17在OP中的作用机制作一综述，以期为今后临床对“免疫-骨质疏松症”领域研究提供一定参考价值。 |
| 英文摘要: |
| The combined study of immune-osteoporosis is a new research field for the role of immune system in osteoporosis (OP). Interleukin-17 (IL-17) is an inflammatory factor, which is secreted by activated immune T lymphocytes 17 (Th17). Modern studies have shown that IL-17 inhibits osteogenic differentiation of mesenchymal stem cells (MSCs) and inhibits osteoblast by acting on related proteins, genes, signaling pathways, and other pathways. IL-17 inhibits osteoblast (OB) differentiation and its related functions, but promotes osteoclast (OC) differentiation and its function, thus affecting the occurrence of OP. The authors review the mechanism of IL-17 in OP, hoping to provide some reference value for future clinical research in the field of immune-osteoporosis". |
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