| Ovariectomy (OVX) animal model is the most widely used classical model to simulate post-menopausal osteoporosis. However, the application of different species of animals can only show some characteristics of osteoporosis. Therefore, the animal model can not reproduce the overall appearance of human osteoporosis. At the same time, the evaluation of the modeling effect depends on accurate measurement methods, and the appropriate measurement methods can reflect the scientific power and consistency of pathological exploration and curative effect evaluation. This paper reviews the modeling characteristics and application fields of rats, mice, rabbits, and sheep in ovariectomized animal models, as well as the modern evaluation methods used, such as bone mineral density, blood biochemical metabolic indexes, bone histomor-phometry, and biomechanics, so as to provide reference for the selection of animals and meas-urement methods in the research model. |