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| 衰老对骨细胞机械转导功能影响的研究进展 |
| Research advances in effect of aging on osteocyte mechanotransduction |
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| DOI：10.3969/j.issn.1006-7108.2022.12.027 |
| 中文关键词: 骨细胞 衰老 机械转导 骨重塑 骨质疏松 |
| 英文关键词:osteocyte aging mechanotransduction bone remodeling osteoporosis |
| 基金项目:2019-2021年成都中医药大学“杏林学者”学科人才科研提升计划（XSGG2019007） |
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| 中文摘要: |
| 骨细胞能够通过其机械转导功能协调骨骼对机械负荷的适应性反应，以维持骨稳态。随着年龄的增长，骨细胞及其微环境会出现一系列衰老相关的变化。衰老可能损伤骨细胞机械转导功能，引起下游信号的改变，造成骨重塑不平衡，进而导致骨质疏松、脆性骨折等退行性骨病的发生。笔者从“骨细胞复杂的机械转导过程”“骨细胞及其微环境的衰老相关改变”以及“衰老引起的骨细胞机械转导相关信号通路的改变”3个方面进行了综述，并对目前的研究难点和未来的研究方向进行总结和展望，以期为相关研究和衰老骨病防治提供新思路。 |
| 英文摘要: |
| Osteocytes may coordinate the adaptive response of bone to mechanical loading through their roles in mechanotransduction to maintain bone homeostasis. Aging causes a series of changes in osteocytes and their microenvironment that may impair osteocyte mechanotransduction, leading to the imbalance of bone remodeling and the occurrence of degenerative bone diseases, such as osteoporosis and fragile fractures. In this review, we summarizes the mechanism of osteocyte mechanotransduction and discusses the aging-related changes of osteocytes and their microenvironment and the signaling pathways related to aging-related mechanotransduction impairment. Moreover, we summarizes the challenges in current research of osteocyte aging and forecasts future direction for the future investigation and the treatment of aging bone diseases. |
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