| Objective To investigate the relationship between bone metabolic markers and osteoporosis (OP) and abdominal aortic calcification (AAC) in patients on peritoneal dialysis (PD). Methods Eighty patients with PD were enrolled and divided into osteoporosis and non-osteoporosis groups based on the results of dual-energy X-ray bone absorptiometry measurement. Lateral radiographs were taken to assess abdominal aortic calcification, which was classified into three groups according to AAC score (AACS), no calcification, mild, or moderate to severe calcification. Clinical data, biochemical parameters, bone metabolic parameters and bone mineral density (BMD) were collected from all the patients. The factors influencing AACS and osteoporosis were analyzed. Results AACS, CRP, blood phosphorus (P), and β-CTX were significantly higher in the osteoporotic group than those in the non-osteoporotic group in PD patients (P<0. 05). Age, CRP, BNP, blood phosphorus, calcium-phosphorus product (CPP), β-CTX, PTH, and lumbar spine BMD were statistically significant (P<0. 05) when compared among the three groups of AACS. Spearman correlation analysis showed that AACS was positively correlated with age, dialysis age, BMI, CRP, BNP, fasting glucose, β-CTX, and PTH (P<0. 05), but was negatively correlated with lumbar spine BMD (r=-0.294, P<0.01). Binary logistic regression analysis with whether the AACS score was ≥ 5 as the dependent variable (after correction for confounders) showed that age, CPP, and β-CTX were independent risk factors. Logistic regression analysis with whether PD patients had concomitant osteoporosis as the dependent variable revealed β-CTX as its independent risk factor. Conclusion In PD patients, β-CTX can be used as an indicator to monitor the severity of AAC and to predict the occurrence of osteoporosis. |