| Osteoporosis (OP) is a systemic bone metabolic disease caused by a variety of pathological factors. In recent years, it has become a public health problem of global concern because of its high incidence and disability rate and unknown pathogenesis. In the past, it was generally believed that the only regulated mode of cell death was apoptosis, and cell necrosis was not regulated. With the continuous development of modern molecular biology technology, it is found that cell necrosis is also regulated by some genes and protein pathways. Therefore, apoptosis, necroptosis, ferroptosis, and pyroptosis all belong to programmed cell death (programmed cell death, PCD), which is an important part of biological development and pathological characteristics. PCD may affect bone metabolic microenvironment and bone metabolic balance, and play an important role in the occurrence and development of OP. This paper reviews the research in the relationship between PCD and OP, in order to provide a new strategy for the prevention and treatment of OP. |