| Based on its success in other chronic diseases, treat-to-target is now considered to be an effective strategy for the treatment of osteoporosis. However, selecting and setting convenient and effective targets are major difficulty in the implementation of treat-to-target of osteoporosis. At present, the treatment targets available for selection have their own characteristics, advantages, and disadvantages. For example, bone mineral density, as the gold standard for the diagnosis of osteoporosis, takes a long time to reach the currently recommended target parameter, or even has not changed significantly for a long time. Furthermore, it is impossible to judge whether early treatment fails and to effectively solve the problem of poor treatment compliance. At the same time, many literature show that grip strength and pain score are closely related to bone mineral density, which can be used as an index to measure treatment. As a new alternative index to evaluate the microstructure of lumbar trabecular bone independent of bone mineral density, trabecular bone score can not only be used to adjust FRAX score, but also improve the ability of fracture risk prediction, which provides a new choice for the evaluation of treat-to-target effect. This paper reviews the current research progress of treat-to-target of osteoporosis. |