| Angiogenesis and osteogenesis are important components of bone growth and development and maintenance of bone mass. The mutual coupling between them runs through the whole process of bone growth and bone remodeling. It plays an important role in osteoporosis and so on. Blood vessels can not only promote bone development, reconstruction and repair by transporting oxygen, nutrients, growth factors and metabolic wastes to bones, but also promote bone growth by secreting factors, signal transmission, and function regulation. With the discovery of H-type blood vessels, the effect of angiogenesis-osteogenesis coupling mechanism on the treatment of osteoporosis has been broadened. Vascular endothelial growth factor, platelet-derived growth factor-BB, angiopoietin-1, alkaline Fibroblast growth factor, transforming growth factor β, hypoxia-inducible transcription factor-1α, axon guidance molecule 3 and sonic hedgehog can promote bone formation by enhancing osteogenic differentiation ability. The prevention and treatment of osteoporosis by modern medicine is mainly by increasing estrogen, calcium content and calcitonin, etc., but its safety is poor. In recent years, the efficacy of traditional Chinese medicine in the prevention and treatment of osteoporosis is quite good. With the in-depth research in the fields of network pharmacology and cell biology, it is found that traditional Chinese medicine can prevent and treat osteoporosis by regulating the related factors of angiogenesis-osteogenesis. This paper By reviewing the relevant research results, we can provide new diagnosis and treatment ideas and targets for the prevention and treatment of osteoporosis by traditional Chinese medicine. |