| Objective To observe the changing level of immune regulating factor transforming growth factor-β ( TGF- β), interleukin 17 (IL-17) , tumor necrosis factor-α(TNF-α) and bone mineral density (BMD), study the correlation between immune regulatory factors and bone mineral density. Methods 163 PMOP patients visited in our hospital from May 2019 to June 2020 were selected to collect general information, including age, height, weight and menopausal age. All patients were measured the levels of BMD, TGF- β1, IL-17, and TNF- α before and after treatment。Results After one year of treatment, BMD of lumbar vertebrae and the neck?of femur were all increased, and the difference was statistically significant (P<0.05), while BMD of total hip elevated slightly and had no statistic significance (P>0.05). The levels of IL-17and TNF- α were decreased, and there were statistically significant difference(P<0.05). The level of TGF-β1 was higher than that before treatment (P<0.05). IL-17 and TNF-α were negatively correlated with BMD(r= – 0.608, r= – 0.494 respectively), and TGF- β 1 was positivelycorrelated with BMD(r=0.474). There are all statistically significant (P<0.05). Conclusion The results of this study show that there was a correlation between immune regulatory factors and BMD, suggesting that the clinical application of immune regulatory factors and BMD could be considered to observe the therapeutic effect of PMOP patients. |