中国骨质疏松杂志

CircRNA_0001795及CircRNA_0048211在老年骨质疏松症中的表达

Expression of CircRNA_0001795 and CircRNA_0048211 in elderly osteoporosis

DOI：10.3969/j.issn.1006-7108.2023.02.007

中文关键词: 骨质疏松症老年人骨密度 CircRNA_0001795 CircRNA_0048211

英文关键词:osteoporosis elderly bone mineral density CircRNA_0001795 CircRNA_0048211

基金项目:海南省医药卫生科研基金项目（20A200008）

作者	单位
张恒林* 吴克弟王声威刘景新	海南西部中心医院骨科，海南儋州 571799

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中文摘要:

目的探讨血清CircRNA_0001795及CircRNA_0048211表达水平对老年骨质疏松症（osteoporosis，OP）的诊断价值及其与骨密度（bone mineral density, BMD）的关系。方法对2019年1月至2021年12月在海南西部中心医院体检的350名老年人进行BMD测量，分为OP组（n=145）、骨量减少组（n=156）和正常骨量组（n=49），比较各组血清CircRNA_0001795及CircRNA_0048211表达水平。应用多因素Logistic回归分析老年OP发生的影响因素，绘制ROC曲线分析CircRNA_0001795及CircRNA_0048211对老年OP的诊断价值。采用Pearson相关分析血清CircRNA_0001795及CircRNA_0048211表达水平与BMD的相关性。结果 OP组血清CircRNA_0001795（0.31±0.08 vs 1.24±0.51，2.28±0.96）及CircRNA_0048211（0.26±0.05 vs 0.91±0.40，1.63±0.58）表达水平均明显低于骨量减少组和正常组（P<0.001）。多因素Logistic回归分析显示，年龄（OR=1.684，95% CI：1.163～2.995）、PTH（OR=2.416，95% CI：1.702～5.883）、CircRNA_0001795（OR=3.108，95% CI：2.493～9.428）及CircRNA_0048211（OR=1.942，95% CI：1.335～4.117）是老年OP发生的影响因素（P<0.05）。CircRNA_0001795及CircRNA_0048211最佳截断值分别为0.85、0.68，二者联合诊断老年OP的AUC最大（0.918，95% CI：0.857～0.977），其准确性为91.2%。相关分析显示，老年OP患者血清CircRNA_0001795（r= 0.804，P<0.001）及CircRNA_0048211（r= 0.775，P<0.001）表达水平与BMD均呈正相关。结论 CircRNA_0001795及CircRNA_0048211在老年OP患者中呈低表达，其与BMD密切相关，二者联合检测对老年OP诊断具有很好的价值。

英文摘要:

Objective To investigate the diagnostic value of serum CircRNA_0001795 and CircRNA_0048211 expression level in elderly osteoporosis (OP) and its relationship with bone mineral density (BMD). Methods The BMD was measured in 350 elderly patients who underwent physical examination in Hainan West Central Hospital from January 2019 to December 2021, and they were divided into OP group (n=145), reduced bone mass group (n=156) and normal bone mass group (n=49). The expression levels of serum CircRNA_0001795 and CircRNA_0048211 in each group were compared. Multivariate Logistic regression was used to analyze the influence factor of elderly OP, and ROC curve was drawn to analyze the diagnostic value of CircRNA_0001795 and CircRNA_0048211 for elderly OP. The correlation between serum CircRNA_0001795 and CircRNA_0048211 expression levels and BMD were analyzed by Pearson correlation analysis. Results The OP group serum CircRNA_0001795 (0.31±0.08 vs 1.24±0.51, 2.28±0.96) and CircRNA_0048211 (0.26±0.05 vs 0.91±0.40, 1.63±0.58) were significantly lower than those in reduced bone mass group and normal group (P<0.001). Multivariate Logistic regression analysis showed that age (OR=1.684, 95% CI: 1.163-2.995), PTH (OR=2.416, 95% CI: 1.702-5.883), CircRNA_0001795 (OR=3.108, 95% CI: 2.493-9.428) and CircRNA_0048211 (OR=1.942, 95% CI: 1.335-4.117) were influence factor for elderly OP (P<0.05). The best truncation values of CircRNA_0001795 and CircRNA_0048211 were 0.85 and 0.68, respectively. The AUC of the combined diagnosis of elderly OP by CircRNA_0001795 and CircRNA_0048211 was the largest (0.918, 95% CI: 0.857-0.977), and its accuracy was 91.2%. Correlation analysis showed that the expression levels of CircRNA_0001795（r= 0.804, P<0.001） and CircRNA_0048211（r= 0.775, P<0.001）were positively correlated with BMD in elderly OP patients. Conclusion CircRNA_0001795 and CircRNA_0048211 are low expressed in elderly OP patients, which are closely related to BMD. The combined detection of the two has a good value for the diagnosis of elderly OP.

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