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| 原发性干燥综合征合并原发性胆汁性肝硬化患者骨密度分析 |
| Analysis of bone mineral density in patients with primary Sjogren's syndrome and primary biliary cirrhosis |
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| DOI：10.3969/j.issn.1006-7108.2023.02.010 |
| 中文关键词: 干燥综合征 原发性胆汁性肝硬化 骨质疏松 骨密度 骨折风险 |
| 英文关键词:primary Sjogren’s syndrome primary biliary cirrhosis osteoporosis bone mineral density fracture risk |
| 基金项目:内蒙古自治区卫生健康科技计划项目（202202232） |
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| 中文摘要: |
| 目的 回顾性分析原发性干燥综合征（primary sjogren's syndrome，pSS）合并原发性胆汁性肝硬化（primary biliary cirrhosis，PBC）患者3D骨密度特点和骨折风险，并分析骨量变化与疾病活动度的关系。方法 选取2017-2021年于内蒙古科技大学包头医学院第一附属医院风湿免疫科诊断为pSS的患者64例，其中pSS合并PBC的患者33例，pSS未合并PBC的患者31例，两组患者的年龄及性别差异均无统计学意义。结果（1）pSS合并PBC组的腰椎二维骨密度（bone mineral density，BMD）较pSS未合并PBC组降低（P＜0.05）；（2）pSS合并PBC组股骨BMD较pSS未合并PBC组降低（P＜0.05）；（3）pSS合并PBC组股骨3D体积骨密度明显低于pSS未合并PBC组（P＜0.05）；（4）pSS合并PBC组患者的10年骨折风险明显高于pSS未合并PBC组的患者，两组相比差异有统计学意义；（5）pSS合并PBC组患者的胆红素水平与10年骨折风险、3D体积骨密度中的Inter Tro骨小梁有相关性（P＜0.05）；与3D体积骨密度中的Inter Tro骨皮质、Inter Tro全部及股骨BMD均无相关性（P＞0.05）；（6）pSS合并PBC组患者的血沉（ESR）、C-反应蛋白(CRP)、免疫球蛋白与股骨3D体积骨密度、10年骨折风险均无相关性（P＞0.05）；（7）pSS合并PBC组患者的谷丙转氨酶(ALT)、谷草转氨酶(AST)、r-谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)与股骨3D体积骨密度、10年骨折风险均无相关性（P＞0.05）。结论 pSS合并PBC患者比pSS未合并PBC患者骨量减少增加、进一步导致骨质疏松以及骨折的风险增加，为pSS合并PBC患者早期骨质疏松的防治提供理论依据。 |
| 英文摘要: |
| Objective The 3D bone mineral density characteristics and fracture risk of patients with primary Sjogren's syndrome (pSS) complicated with primary biliary cirrhosis (PBC) were retrospectively analyzed, and the relationship between bone mass change and disease activity was analyzed. Methods From 2017 to 2021, 64 patients diagnosed with pSS were selected from Department of Rheumatology and Immunology, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, including 33 patients with pSS-PBC and 31 patients with pSS-non-PBC. There was no statistical difference in age and gender between the two groups. Results (1) Lumbar bone mineral density (BMD) in pSS combined with PBC group was lower than that in pSS without PBC group (P<0.05). (2) The femur BMD of pSS combined with PBC group was lower than that in pSS without PBC group (P<0.05). (3) The femoral 3D BMD in pSS combined with PBC group was significantly lower than that in pSS without PBC group (P<0.05). (4)The 10-year fracture risk of patients with pSS combined with PBC was significantly higher than that in pSS without PBC, with statistical difference between the two groups. (5) The bilirubin level in pSS combined with PBC group was correlated with 10-year fracture risk and Inter Tro trabecular bone in 3D volume bone density (P<0.05). There was no correlation between Inter Tro bone cortex, Inter Tro all in 3D volume BMD, and femoral BMD (P>0.05). (6) Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and immunoglobulin were not correlated with femoral 3D volume BMD and 10-year fracture risk in patients with pSS combined with PBC (P>0.05). (7) ALT, AST, GGT, and ALP were not correlated with femoral 3D volume BMD and 10-year fracture risk in patients with pSS combined with PBC (P>0.05). Conclusion Patients with pSS combined with PBC have an increased bone mass reduction, further causing osteoporosis, and an increased risk of fracture compared with pSS patients without combined with PBC. This provides a theoretical basis for the prevention and treatment of early osteoporosis in pSS patients with PBC. |
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